The aim of the present study is to observe and comparatively study the academic stress and mental health of the students of standard 12th. The number of students is 160 living and studying in the city area of Rajkot.They were further categorized into 80 boy students and 80 girl students. The sample was randomly selected. The Research Tools are: (1) Academic Stress Inventory developed by Dr. Kasandariya Harsha, (2) Mental Hygiene Inventory developed by Dr. D. J. Bhatt and Gita Gida. The collected data was analyzed by ‘t’ test and ‘r’ correlation method.There was no significant difference between boy and girl students’ academic stress and mental health but there was significant difference between Academic Stress and Mental Healthhe aim of the present study is to observe and comparatively study the academic stress and mental health of the students of standard 12th. The number of students is 160 living and studying in the city area of Rajkot.They were further categorized into 80 boy students and 80 girl students. The sample was randomly selected. The Research Tools are: (1) Academic Stress Inventory developed by Dr. Kasandariya Harsha, (2) Mental Hygiene Inventory developed by Dr. D. J. Bhatt and Gita Gida. The collected data was analyzed by ‘t’ test and ‘r’ correlation method.There was no significant difference between boy and girl students’ academic stress and mental health but there was significant difference between Academic Stress and Mental HealthKeywords: comparative study, t’ test and ‘r’ correlation method, boy and girl students’ academic stress and mental health.